Framework/Architectural options for Web Application for Asp.NET developers

Asp.Net Form based

• ASP.NET pure server side application + JQUERY for minor DOM manipulation
• ASP.NET + Ajax.NET + JQUERY for minor DOM manipulation
• ASP.NET  + ASP.NET Ajax toolkit library + JQUERY for minor DOM manipulation

Asp.Net MVC based

• ASP.NET MVC + JQUERY for minor DOM manipulation
• ASP.NET MVC  along with ASP.NET WebAPI / WCF  + JQUERY for API Calls and DOM manipulation

Client UI framework/library based

• JQUERY for API Calls and DOM manipulation  + ASP.NET WebAPI/ WCF 
• Angular JS + ASP.NET WebAPI/ WCF

Note : 

• There are tons of JQUERY plugin available over the web when we use it for DOM manipulations.
• While writing client UI Framework based applications various JQUERY based controls are generally used.